Understanding The Role of Mitochondria in The Processes of Differentiation of Mesenchymal Stem/ Progenitor Cells and Male Germ Cells in Case of Male Infertility

Differentiation of derived from in vitro-incubated adult human mesenchymal stem cells (MSCs), isolated bone marrow, cartilage and adipose tissue, respectively, by application appropriate incubation conditions, to osteoclasts, was investigated proved. The current results show the importance changes mitochondrial dynamics about differentiation male germ (spermatogonia) mature functional activity gametes (spermatozoa), as well MSCs direction osteoclasts thus, receptor activator tartrate-resistant acid phosphatase (TRAP). In this way, were agreement with literature data confirmed key role these organelles stem/progenitor cells. Furthermore, a possibility for development new mitochondria-based strategies needs regenerative medicine assisted reproduction could be proposed.